Key result · Figure redrawn from the paper
Odds ratio for atrial fibrillation per genetically predicted increase in each protein (95% CI)
Independent research · 2026
Inflammatory Proteins & Risk of Atrial Fibrillation: A Mendelian Randomization Study
I used inherited genetic variants as natural experiments to test which inflammatory proteins may actually cause atrial fibrillation, the most common heart-rhythm disorder, rather than just appearing alongside it.
- Strongest signal: IL-6 receptor, replicated by three independent instruments
- Methods: two-sample MR in R; IVW and Wald ratio, MR-Egger, Steiger and leave-one-out tests, Bonferroni and FDR correction